Understanding nutritional challenges in critical illness and stroke
Critical illness or injury triggers profound physiological changes, creating a hypermetabolic state characterized by increased nutritional needs and energy requirements. This heightened metabolic demand, which is at its highest within the first week or so of illness or surgery, can rapidly lead to muscle wasting, compromised immune function, and delayed wound healing.
Meanwhile, intensive care unit (ICU) patients often face barriers to adequate oral nutrition, including altered consciousness, sedation, mechanical ventilation, and swallowing difficulties. In these situations, classic feeding may be impossible and other options must be considered.
Swallowing problems, or dysphagia, are particularly common following stroke, occurring in up to 78% of patients1. This increases the risk of aspiration pneumonia, malnutrition , dehydration, and prolonged hospital length of stay2-3. Similarly, critically ill patients with impaired gastrointestinal function face challenges in nutrient absorption, making specialized nutrition support crucial for their recovery.
Consequences of malnutrition on critical care outcomes
Malnutrition significantly impacts patient outcomes in critical care and stroke recovery. Nutritional deficiencies are closely associated with increased mortality, prolonged ventilation requirements, higher rates of infections including ventilator-associated pneumonia, and delayed healing processes. The risk of malnutrition is particularly high in patients who receive prolonged mechanical ventilation4-5.
Systematic reviews and randomized trials have demonstrated the strong link between poor nutritional status and suboptimal recovery. For instance, upon ICU admission, sub-acute stroke patients without dysphagia still commonly exhibit lower blood levels of critical nutrients, highlighting the prevalence and impact of malnutrition even in less obvious cases6.
Research from the Society of Critical Care Medicine confirms that addressing malnutrition promptly and effectively is essential to improve survival rates, is associated with lower hospital length of stay, and facilitate better long-term rehabilitation outcomes. The NUTRIC score is often used to identify patients who would benefit most from aggressive nutrition therapy7-10.
Enteral nutrition: an essential strategy in critical care
When oral nutrition is not possible or sufficient, especially in critical care settings, alternative feeding methods become essential. Enteral nutrition delivers nutrients directly to the gastrointestinal tract via tube feeding, supporting intestinal function and integrity while maintaining the gut microbiota . Early enteral nutrition is generally used whenever gastrointestinal function remains intact, as it helps preserve gut barrier function, reduces infection risks, and supports overall recovery11.
Nutritional strategies to enhance recovery, resilience, and gastrointestinal tolerance
Nutritional interventions in critically ill adults should be based on extensive scientific evidence and clinical insights, tailored to specific patient needs. These interventions prioritize early nutritional support, gastrointestinal tolerance, and patient-specific adaptations.
Early goal-directed nutrition in ICU patients
Research emphasizes initiating nutritional therapy within the first 24-48 hours of intensive care unit admission or post-stroke event. Early-goal directed nutrition significantly reduces complications and improves outcomes. Randomised trials support early feeding protocols incorporating oral nutritional supplements, enteral tube feeding12, or supplemental parenteral nutrition to ensure adequate nutrient delivery from the earliest stages of care.
High-protein and energy-dense solutions
Critical illness and stroke recovery demand higher protein and caloric intake to counteract muscle breakdown and promote healing. Advanced formulations rich in protein, micronutrients, and omega-3 fatty acids are vital for immune support, wound healing13, and muscle preservation. Accurate assessment of energy expenditure helps prevent both underfeeding and overfeeding in adult critically ill patients14.
Targeting gastrointestinal tolerance
Gastrointestinal intolerance is a common challenge in critically ill patients, affecting nutritional absorption and patient comfort. Innovative nutritional solutions prioritize optimal gastrointestinal tolerance through advanced ingredient selections, including easily digestible proteins, medium-chain triglycerides (MCTs), and soluble fiber. These specialized formulations improve gut motility and nutrient absorption, reducing complications such as diarrhea and constipation, and helping to maintain proper energy balance15.
Addressing Dysphagia
Recognizing the prevalence of dysphagia post-stroke, tailored, texture-modified nutritional products ensure safe swallowing, reduce aspiration risk, and optimize nutrient intake. These carefully formulated products allow patients with swallowing difficulties to achieve their nutritional goals safely and effectively16-17.
Nutrition in critically ill patients with special conditions
Certain patient populations require specialized approaches to nutritional support. Patients with acute kidney injury, those in surgical ICU settings, and ventilated adults with shock may all have unique nutritional requirements. Permissive underfeeding or standard enteral feeding in high-risk patients remains controversial, with multiple randomized trials showing varying results18-20.
Danone and scientific innovation in critical care nutrition
In intensive care, pre or post-operation, nutrition is an essential aspect of care that supports other medical practices. On its own, it will not heal people, but it will greatly influence the way in which they recover from their illness or accident. Partnerships with intensive care specialists, neurologists, speech therapists and nutritionists enable the development and validation of innovative nutritional approaches based on the latest literature.
At Danone Research & Innovation, we set apart by following a rigorous scientific approach to nutrition in critical care. Our research teams develop nutritional solutions specifically targeting gastrointestinal tolerance, a major challenge for critically ill patients. These innovations are based on specific formulations including easily digestible dairy or plant-based proteins, medium-chain triglycerides and soluble fibers that improve intestinal motility and nutrient absorption, thus reducing complications such as diarrhea and constipation.
For surgical patients, we have developed nutritional protocols that align with ERAS (Enhanced Recovery After Surgery) programs. These optimized perioperative interventions have significantly reduced postoperative complications and the length of hospital stay.
Moreover, through our numerous collaborations, we can also raise awareness about malnutrition. These insights allow us to help patients prepare for surgery and provide them with effective support during their hospital stay and recovery.
Effective nutritional management is crucial for patients recovering from stroke or experiencing critical illness. Through ongoing research, advanced product development, and strong clinical collaborations, Danone R&I continue to evolve nutritional strategies to optimize recovery, enhance resilience, and ultimately restore patients' quality of life in even the most challenging healthcare contexts.
- Martino R, et al. Stroke 2005; 36: 2756-63
- Bouziana SD, et al. J Nutr Metab 2011
- Geeganage C, et al. Cochrane. Database Syst. Rev. 2012
- Al Tamimi D, Ahmad M. Risk of Malnutrition and Clinical Outcomes Among Mechanically Ventilated Patients in Intensive Care Units. Dimens Crit Care Nurs. 2022 Jan-Feb 01;41(1):18-23. doi: 10.1097/DCC.0000000000000504. PMID: 34817957.
- Chiang, CY., Lan, CC., Yang, CH. et al. Investigating the differences in nutritional status between successfully weaned and unsuccessfully weaned respirator patients. Sci Rep 13, 7144 (2023). https://doi.org/10.1038/s41598-023-34432-0
- Van Wijk N, Studer B, van den Berg CA, Ripken D, Lansink M, Siebler M, Schmidt-Wilcke T. Evident lower blood levels of multiple nutritional compounds and highly prevalent malnutrition in sub-acute stroke patients with or without dysphagia. Front Neurol. 2023 Jan 10;13:1028991. doi: 10.3389/fneur.2022.1028991. PMID: 36703642; PMCID: PMC9872791.
- www.criticalcarenutrition.com/docs/PEPuPCollaborative/NUTRIC+Score+1+page+summary_19March2013.pdf
- Zhang P, Bian Y, Tang Z, Wang F. Use of Nutrition Risk in Critically Ill (NUTRIC) Scoring System for Nutrition Risk Assessment and Prognosis Prediction in Critically Ill Neurological Patients: A Prospective Observational Study. JPEN J Parenter Enteral Nutr. 2021 Jul;45(5):1032-1041. doi: 10.1002/jpen.1977. Epub 2020 Aug 18. PMID: 32729938.
- Lin, Pi-Yia,b; Yen, Yu-Tongc; Lam, Chee-Tatd; Li, Kuan-Chene; Lu, Ming-Jenb,d; Hsu, Han-Shuia,f,*. Use of modified-NUTRIC score to assess nutritional risk in surgical intensive care unit. Journal of the Chinese Medical Association 84(9):p 860-864, September 2021. | DOI: 10.1097/JCMA.0000000000000565
- www.ijccm.org/doi/10.4103/ijccm.IJCCM_24_17
- Szefel J, Kruszewski WJ, Buczek T. Enteral feeding and its impact on the gut immune system and intestinal mucosal barrier. Prz Gastroenterol. 2015;10(2):71-7. doi: 10.5114/pg.2015.48997. Epub 2015 Feb 6. PMID: 26557936; PMCID: PMC4631273.
- Doig GS, Heighes PT, Simpson F, Sweetman EA, Davies AR. Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta-analysis of randomised controlled trials. Intensive Care Med. 2009 Dec;35(12):2018-27. doi: 10.1007/s00134-009-1664-4. Epub 2009 Sep 24. PMID: 19777207.
- Van Zanten ARH, De Waele E, Wischmeyer PE. Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases. Crit Care. 2019 Nov 21;23(1):368. doi: 10.1186/s13054-019-2657-5. PMID: 31752979; PMCID: PMC6873712.
- https://resources.wfsahq.org/atotw/nutritional-considerations-for-icu-patients-part-1-when-what-and-how-to-feed/
- https://www.espen.org/files/ESPEN-Guidelines/ESPEN_practical_and_partially_revised_guideline_Clinical_nutrition_in_the_intensive_care_unit.pdf
- www.binasss.sa.cr/bibliotecas/bhm/mar24/51.pdf
- Raheem D, Carrascosa C, Ramos F, Saraiva A, Raposo A. Texture-Modified Food for Dysphagic Patients: A Comprehensive Review. Int J Environ Res Public Health. 2021 May 12;18(10):5125. doi: 10.3390/ijerph18105125. PMID: 34066024; PMCID: PMC8150365.
- Reintam Blaser A, Rooyackers O, Bear DE. How to avoid harm with feeding critically ill patients: a synthesis of viewpoints of a basic scientist, dietitian and intensivist. Crit Care. 2023 Jul 1;27(1):258. doi: 10.1186/s13054-023-04543-1. PMID: 37393289; PMCID: PMC10314407.
- Patel JJ, Martindale RG, McClave SA. Controversies Surrounding Critical Care Nutrition: An Appraisal of Permissive Underfeeding, Protein, and Outcomes. JPEN J Parenter Enteral Nutr. 2018 Mar;42(3):508-515. doi: 10.1177/0148607117721908. Epub 2017 Dec 12. PMID: 28742432.
- Arabi YM, Tamim HM, Sadat M. Reply to Compher et al.: Reservations about Permissive Underfeeding in Low versus High NUTRIC Patients? Am J Respir Crit Care Med. 2018 May 1;197(9):1228-1229. doi: 10.1164/rccm.201712-2394LE. PMID: 29236520.